Reproductive immunology and
lipid infusion therapy
What is infertility?
The term infertility basically refers to the inability to conceive. According to medical terminology, a couple is considered infertile if they fail to conceive for six months to a year (depending on age) without regular unprotected sex.
Infertility can affect both women and men and can be caused by a variety of reasons. These may be genetic factors, lifestyle factors, diseases or psychosomatic factors. Coping with infertility is a serious emotional and mental challenge for couples.
Because of the seriousness of the problem, it is important to understand the possible causes of infertility.
Finding the causes of infertility
When investigating the background of infertility, it is important to carry out a thorough medical examination of both members of the couple.
In women, the most common causes of infertility include a gynaecological problem (e.g. endometriosis, blockage of the fallopian tubes), hormonal abnormalities or an immune system disorder. In many cases, it can be a combination of several different conditions.
The most common causes of male infertility are low sperm count or poor sperm motility. Genetic factors may also play a role.
Dr. Angéla Fülöp
Immunologist and rheumatologist
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What is reproductive immunology?
Immunology, the science of how the immune system works, has become increasingly important in recent decades in the investigation and treatment of the causes of infertility.
The link between infertility and immunology is based on the thesis that immune dysfunction can contribute to infertility. In fact, the immune system is not only involved in the defence against infections and diseases, but also plays a key role in reproductive processes.
During the immune system, different cells coordinate the body’s defence mechanisms. Normally, the immune system recognises and destroys harmful pathogens, but sometimes the system can malfunction and the body turns against its own cells.
This autoimmune reaction can lead to infertility and recurrent miscarriages.
Prevalence of vaccinations and the immune response
The relationship between miscarriage rate and immune function is a particularly important area of research in reproductive immunology. Several studies have shown that immune dysfunction is associated with early miscarriages. If the fetus passes several times in early pregnancy, but there are no hormonal or organ problems, it is likely to be due to an issue related to immunology.
When examining the immune system, it is important to know that both innate and acquired immunity can be disturbed. In both cases, the body turns on itself and attacks the embryo as a hostile entity.
The following immune disorders may be associated with reproductive immunology:
- Systemic immune diseases – Autoimmune diseases in which the immune system attacks not a single organ, but several organ systems or the whole body, such as systemic lupus erythematosus (SLE).
- Alloimmunity disorder – An immune response in which the body rejects the fetus or already prevents it from attaching.
- Organ-specific immune diseases – Autoimmune diseases in which the immune system specifically attacks the cells of a particular organ, which may be the ovaries. As a result, the chance of becoming pregnant is greatly reduced.
How are miscarriage and immune response linked?
To understand the link between miscarriage and the immune response, it is important to consider that during pregnancy, the embryo is semi-open to the female body, as it also contains the paternal gene pool. Normally, the immune system recognises this semi-foreign tissue and develops a tolerance to it, allowing the pregnancy to develop without disturbance.
However, in some cases, the immune system cannot properly recognise and tolerate the embryo, which can lead to autoimmune reactions. This is particularly common in women who suffer from autoimmune diseases such as lupus or thyroid disorders.
Research into the link between miscarriages and the immune response has discovered that the presence of certain antibodies can also increase the risk of miscarriage. Antiphospholipid antibody syndrome (APS), for example, is a condition in which the body produces antiphospholipid antibodies that can interfere with blood clotting and placental function, causing miscarriage.
The role of diagnosis
Diagnosing problems in reproductive immunology is a complex process involving many tests and examinations.
Blood tests are performed on couples to measure the presence of antibodies that may attack the embryo or sperm. Hormonal tests and genetic tests may also be needed to get a full picture of the immune system and its impact on reproductive health.
Dr. Angéla Fülöp, immunologist and rheumatologist, can be reached at
lipid infusion therapy
Dr. Angéla Fülöp is an immunologist, whose task is to detect and treat immune-derived lesions. She does this with great expertise and decades of experience.
Lipid infusion for infertility treatment is available on prescription.
Find out more about the Doctor and make an appointment!
How to tackle the problem of reproductive immunology?
Treatment of problems in reproductive immunology requires a complex and personalised approach. One of the most effective treatment methods is lipid infusion therapy, which has become increasingly popular in recent years.
What is a lipid infusion?
Lipid infusion treatment involves the intravenous administration of lipids (fatty acids), vitamins and trace elements, among other things, to help regulate the immune system. This treatment can be particularly useful for women whose immune system is overactive and attacks the embryo, preventing successful implantation and pregnancy retention.
The effectiveness of lipid infusions lies in their ability to help reduce inflammation and promote embryo implantation in the uterine lining. They also support cell-to-cell communication and improve blood flow to the reproductive organs, further increasing the chances of a successful pregnancy.
Lipid infusion therapy is safe and has minimal side effects. It aims to maximise the chances of a successful pregnancy. The treatment protocol is personalised and based on individual needs and medical findings.
Immunology in the BMM
The immune system is extremely complex. Immunology is concerned with the detection of its disorders. The immune system’s primary role is to protect the body against pathogens, ensuring that the body stays healthy.
During immunology examinations, doctors carry out various tests to identify possible disorders of the immune system.
These tests may include blood tests, detection of the presence of autoantibodies and assessment of specific immune responses. Immunology tests are designed to detect if the immune system is malfunctioning, for example, if it is attacking your own body’s cells or if it is not responding properly to external pathogens.
With this information, the specialist immunologist will develop a targeted treatment plan to restore optimal immune function.
In the case of infertility, tests in the field of immunology can help to understand how a malfunctioning immune system may be contributing to difficulties in conception. Based on this information, appropriate treatment, such as lipid infusions, can increase the chances of getting pregnant. Dr Angéla Fülöp, an expert in immunology, can also help with this .
Our specialist immunologist in immunology
Dr. Angéla Fülöp
Immunologist and rheumatologist
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